High Diversity in Functional Properties of Melanocortin 1 Receptor (MC1R) in Divergent Primate Species Is More Strongly Associated with Phylogeny than Coat Color
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چکیده
منابع مشابه
High diversity in functional properties of melanocortin 1 receptor (MC1R) in divergent primate species is more strongly associated with phylogeny than coat color.
We have characterized the biochemical function of the melanocortin 1 receptor (MC1R), a critical regulator of melanin synthesis, from 9 phylogenetically diverse primate species with varying coat colors. There is substantial diversity in melanocyte-stimulating hormone (MSH) binding affinity and basal levels of activity in the cloned MC1Rs. MSH binding was lost independently in lemur and New Worl...
متن کاملMelanocortin receptor 1 (MC1R) mutations and coat color in pigs.
The melanocortin receptor 1 (MC1R) plays a central role in regulation of eumelanin (black/brown) and phaeomelanin (red/yellow) synthesis within the mammalian melanocyte and is encoded by the classical Extension (E) coat color locus. Sequence analysis of MC1R from seven porcine breeds revealed a total of four allelic variants corresponding to five different E alleles. The European wild boar poss...
متن کاملGenetics of Coat Color I: The Melanocortin 1 Receptor (MC1R)
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متن کاملPolymorphisms in Melanocortin Receptor 1 Gene in Goat Breeds: A Window for Coat Color Controling Mechanism
The broad goal of this research was to examine the nature of the Melanocortin receptor 1 (MC1R) locus on the coat color phenotype of seven goat breeds with different color coat. Blood samples were collected from five Iranian indigenous (Khalkhal, Markhor, Naeini, Najdi and Tali) and two exotic (Cashmere and Saanen) goat breeds. Polymerase chain reaction restriction fragment length polymorphism ...
متن کاملpolymorphisms in melanocortin receptor 1 gene in goat breeds: a window for coat color controling mechanism
the broad goal of this research was to examine the nature of the melanocortin receptor 1 (mc1r) locus on the coat color phenotype of seven goat breeds with different color coat. blood samples were collected from five iranian indigenous (khalkhal, markhor, naeini, najdi and tali) and two exotic (cashmere and saanen) goat breeds. polymerase chain reaction restriction fragment length polymorphism ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2007
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msm134